Tenobis Plus 5mg Tablet 14pcs

Uses of Tenobis Plus 5mg Tablet

Hypertension, Congestive heart failure, HTN, Angina pectoris.

How does Tenobis Plus 5mg Tablet work?

Bisoprolol Fumarate is a β1-selective adrenoceptor blocking agent, and Hydrochlorothiazide is a benzothiadiazine diuretic. Their additive effects help in treating hypertension.

Side Effects of Tenobis Plus 5mg Tablet

Generally well-tolerated with mild and transient side effects. Possible side effects include fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest pain, palpitations, cold extremities, claudication, orthostatic hypotension, diarrhea, constipation, nausea, dyspepsia, rhinitis, pharyngitis, and others.

Quick Suggestions:

• A combination drug for hypertension; taken with or without food.
• Do not stop suddenly; it may cause a sudden rise in blood pressure.
• May cause dizziness; rise slowly from sitting or lying position.
• Monitor blood sugar levels if diabetic, as it can mask symptoms of low blood sugar.
• Stay hydrated; report extreme thirst, muscle weakness, or dry mouth to the doctor.

Indication of Tenobis Plus 5mg Tablet

• Tenobis Plus 5 is prescribed for hypertension (high blood pressure).
• It's a combination of two medicines effective when a single medication isn't sufficient.

Pharmacology:

Bisoprolol Fumarate and Hydrochlorothiazide, when used individually or in combination, are effective in treating hypertension. The antihypertensive effects are additive, and Hydrochlorothiazide 6.25 mg significantly enhances the antihypertensive effect of Bisoprolol Fumarate. Bisoprolol Fumarate is a β1-selective adrenoceptor blocking agent, while Hydrochlorothiazide is a benzothiadiazine diuretic. Thiazides, like Hydrochlorothiazide, influence renal tubular mechanisms of electrolyte reabsorption, leading to increased excretion of sodium and chloride in roughly equivalent amounts.

Dosage & Administration of Tenobis Plus 5mg Tablet

• Initial Therapy: Start with one 2.5/6.25 mg tablet once daily.
• Subsequent Titration: Titrate at 14-day intervals with these tablets, up to the maximum recommended dose of 20/12.5 mg once daily, as appropriate.
• Replacement Therapy: The combination may replace titrated individual components.
• Therapy Guided by Clinical Effect: Adjust based on the patient's response.

OverDose Effect

Limited data; signs may include bradycardia, hypotension, lethargy, delirium, coma, convulsions, respiratory arrest, congestive heart failure, bronchospasm, and hypoglycemia.

Interaction

• This combination may potentiate the action of other antihypertensive agents.
• Avoid combining with other beta-blocking agents.
• Closely monitor patients on catecholamine-depleting drugs.
• Exercise caution when used concurrently with clonidine.
• Use with caution when myocardial depressants or AV conduction inhibitors are employed.

Contraindications

Contraindicated in patients in cardiogenic shock, overt cardiac failure, second or third-degree AV block, marked sinus bradycardia, anuria, and hypersensitivity to either component or other sulfonamide-derived drugs.

Pregnancy & Lactation

• Use in Pregnancy: Category C - Use during pregnancy only if potential benefits justify potential risks.
• Use in Nursing Mothers: Consider the importance of the drug to the mother, as thiazides are excreted in human breast milk.

Precautions & Warnings

• Monitor for hyperuricemia or acute gout.
• Watch for signs or symptoms of fluid and electrolyte imbalance.
• Gradual withdrawal is advised if discontinuing the therapy.
• Observe patients during withdrawal.

Storage Conditions

Store below 30°C, away from light & moisture. Keep out of reach of children.